rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
(3) Stratified by sample type, TLR2 Arg753Gln polymorphism is associated with increased PTB risk, but not with EPTB.
|
30733958 |
2019 |
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Genotyping was performed to detect -196 to -174 del polymorphism and G2258A SNP (Arg753Gln, rs5743708) in TLR2 gene and -T1237C (rs5743836) and G2848A (rs352140) SNP in TLR9 gene in patients with pulmonary TB and healthy controls.
|
29675696 |
2018 |
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
There was a significant association between the GA genotype (heterozygous mutant) of TLR2 Arg753Gln polymorphism and the risk of infection with pulmonary TB (p = 0.003, OR = 4.83) and TB peritonitis (p = 0.003, OR = 6.2).
|
28332241 |
2017 |
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In TLR2, the frequencies of the CC genotype (OR = 2.262; 95% CI: 1.433-3.570) and C allele (OR = 1.566; 95% CI: 1.223-1.900) in single-nucleotide polymorphism (SNP) rs3804100 were significantly higher in the LTBI group than in the HC group, whereas the GA genotype of SNP rs5743708 was associated with PTB (OR = 6.087; 95% CI: 1.687-21.968).
|
25928077 |
2015 |
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A meta-analysis was conducted to investigate the relationship between TLR2 G2</span>258A and T597C polymorphisms with PTB susceptibility.
|
24124467 |
2013 |
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We also showed that the frequencies of the heterozygous Arg753Gln genotype and the Gln allele were significantly higher in patients with pulmonary TB alone and in patients with definitive pulmonary plus extrapulmonary TB than in children with LTBI.
|
21320563 |
2011 |
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
rs5743708
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB).
|
20650298 |
2010 |
rs3804099
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Polymorphisms rs3804099 (TLR2) and rs352139 (TLR9) may also be associated with PTB risk in the Moldavian population but their effect is less consistent across different studies.
|
30529560 |
2019 |
rs3804099
|
|
|
0.040 |
GeneticVariation |
BEFREE |
This study demonstrates that T597C polymorphism of TLR2 is a risk factor for susceptibility to PTB rather than to TBM in a sample of Chinese adult population.
|
26722451 |
2015 |
rs3804099
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Our data suggest that 597T/C polymorphism, but not Arg677Trp polymorphism, of the TLR-2 gene is a risk factor for susceptibility to PTB in a sample of Iranian population.
|
23830055 |
2014 |
rs3804099
|
|
|
0.040 |
GeneticVariation |
BEFREE |
TLR2 2258G allele may provide protective effects against PTB susceptibility, particularly among Asians, whereas TLR2 T597C polymorphism might not be associated with PTB susceptibility.
|
24124467 |
2013 |
rs121917864
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genotyping of TLR2 (Arg753Gln and Arg677Trp) polymorphisms was carried out on 52 patients with pulmonary TB, 44 patients with peritoneal TB, and 50 healthy controls using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
|
28332241 |
2017 |
rs121917864
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data suggest that 597T/C polymorphism, but not Arg677Trp polymorphism, of the TLR-2 gene is a risk factor for susceptibility to PTB in a sample of Iranian population.
|
23830055 |
2014 |
rs3804100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In TLR2, the frequencies of the CC genotype (OR = 2.262; 95% CI: 1.433-3.570) and C allele (OR = 1.566; 95% CI: 1.223-1.900) in single-nucleotide polymorphism (SNP) rs3804100 were significantly higher in the LTBI group than in the HC group, whereas the GA genotype of SNP rs5743708 was associated with PTB (OR = 6.087; 95% CI: 1.687-21.968).
|
25928077 |
2015 |